Maturation of Calcium-Dependent GABA, Glycine, and Glutamate Release in the Glycinergic MNTB-LSO Pathway
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چکیده
منابع مشابه
Maturation of Calcium-Dependent GABA, Glycine, and Glutamate Release in the Glycinergic MNTB-LSO Pathway
The medial nucleus of the trapezoid body (MNTB) is a key nucleus in high-fidelity temporal processing that underlies sound localization in the auditory brainstem. While the glycinergic principal cells of the MNTB project to all primary nuclei of the superior olive, during development the projection from MNTB to the lateral superior olive (LSO) is of interest because this immature inhibitory pro...
متن کاملPre- and postsynaptic properties of glutamatergic transmission in the immature inhibitory MNTB-LSO pathway.
The lateral superior olive (LSO) integrates excitatory inputs driven by sound arriving at the ipsilateral ear with inhibitory inputs driven by sound arriving at the contralateral ear in order to compute interaural intensity differences needed for localizing high-frequency sound sources. Specific mechanisms necessary for developmental refinement of the inhibitory projection, which arises from th...
متن کاملTitle : Pre - and post - synaptic properties of glutamatergic transmission in the immature inhibitory
The lateral superior olive (LSO) integrates excitatory inputs driven by sound arriving at the ipsilateral ear with inhibitory inputs driven by sound arriving at the contralateral ear in order to compute interaural intensity differences needed for localizing high frequency sound sources. Specific mechanisms necessary for developmental refinement of the inhibitory projection, which arises from th...
متن کاملNMDAR-Mediated Calcium Transients Elicited by Glutamate Co-Release at Developing Inhibitory Synapses
Before hearing onset, the topographic organization of the inhibitory sound localization pathway from the medial nucleus of the trapezoid body (MNTB) to the lateral superior olive (LSO) is refined by means of synaptic silencing and strengthening. During this refinement period MNTB-LSO synapses not only release GABA and glycine but also release glutamate. This co-released glutamate can elicit pos...
متن کاملDevelopment of glycinergic innervation to the murine LSO and SPN in the presence and absence of the MNTB
Neurons in the superior olivary complex (SOC) integrate excitatory and inhibitory inputs to localize sounds in space. The majority of these inhibitory inputs have been thought to arise within the SOC from the medial nucleus of the trapezoid body (MNTB). However, recent work demonstrates that glycinergic innervation of the SOC persists in Egr2; En1(CKO) mice that lack MNTB neurons, suggesting th...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2013
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0075688